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Upon activation, free radicals such as nitric oxide (NO) and superoxide are released, which elevates oxidative stress contributing to pathogen elimination and local tissue damage ( Migraine Pathogenesis: Role of Oxidative Stress, Neuroinflammation, and Mitochondrial Dysfunction Migraine is defined as a neurovascular disorder involving cortical spreading depression (CSD), neurogenic inflammation, and dysfunction in cranial vascular contractility ( Oxidative Stress Oxidative stress role in migraine pathogenesis is emphasized by multiple studies

doi: 10.3389/fendo.2023.1119765 127 KucherANazarenkoM

It triggers mitophagy, the selective cleanup of damaged mitochondria

Metabolomic analysis of serum BAss in SZ patients revealed significantly altered BAs profiles compared to healthy controls (80)

Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D, Aralica G, Safic H, Suran J, Rak D, Dzidic S, Vrcic H, Sebecic B

One clinical trial found subjects who supplemented with glutathione had higher levels of natural killer (NK) cells and lymphocytestwo types of cells that fight off infections (9)