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It has also been observed to interact with growth factor pathways, influence extracellular matrix dynamics, and participate in cytoprotective responses under stress conditions

doi:10.1038/s41366-022-01197-x

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By Week 4 of therapy , patients usually reach whats called a steady state , meaning the body has a consistent level of the medication

But stress, aging, hormones, inflammation, poor nutrition, and environmental damage can interfere with this natural process