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The goal is to identify individuals for whom GLP-1 therapy is clinically appropriate and likely to support sustainable outcomes when administered under supervision

[DOI] [PMC free article] [PubMed] [Google Scholar] 85.Ventorp F, Bay-Richter C, Nagendra AS, Janelidze S, Matsson VS, Lipton J, et al

Substituting these amino acids with alanine resulted in a significant decrease in binding affinity and cAMP production

Give it a month on a lower dose, and if no weight gain, I would continue to decrease