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MD simulations on the exendin-P5-bound complex revealed a similar C-terminal interaction pattern to exendin-4 for this peptide, with more persistent interactions with the ECD and TM1/stalk than GLP-1 (Figure 6, Supplemental Figure 11, Supplemental Table 3)

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Traditionally treatment of lcFAODs consists of prevention of catabolism, LCT restriction, and supplementation of MCT [143, 145, 146]

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Studies on gut microbiota-targeted approaches have also revealed biomarkers that can be utilized for both early diagnostic and prognostic purposes in cases of CKD

Compter I, Eekers DB, Hoeben A, Rouschop KM, Reymen B, Ackermans L, et al