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The authors argued that the lack of therapeutic efficacy could be due to systemic distribution or distribution outside the joint after intra-articular injection

the efficiency of meningococcal invasion of HBMEC decreased under L-glutamate-depleted conditions

68,69,70,71,72,73,74 Genetic factors have also been suggested

For dietary deficiency and mild absorption issues, high-dose oral therapy can restore levels without the injection-related local reactions or the tiny chance of anaphylaxis

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Jahng et al., 2017