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Clinical research suggests GLP-1 receptor agonists are safe for long-term weight management under medical supervision

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In Phase 2 trials, maintenance doses included 4mg, 8mg and 12mg once weekly

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Old ANKI mice have enhanced expression of SIRT1 target genes in the hypothalamus [83,84], which is important for physical activity and sleep quality and maintains memory and learning ability, retinal photoreceptor neurons, and further insulin secretion capacity with better glucose tolerance

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