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Similarly, compound like Beta-d-Ribopyranoside, methyl, 3-acetate showed highest binding energy (-6.228 Kcal/Mol) with three H-bonds at Proline (PRO) 421, Neutral Glutamic acid (GLH) 402, Leucine (LEU) 188 residues formation with target protein MMP-9 (pdb id -1GKC)

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and patients with glutathione-S-transferase M1 (proinflammatory-cytokine producer macrophages) null and M1 and T1 (Type 1 helper CD4 + lymphocytes) double null polymorphisms had increased mortality suggesting that antioxidant therapy becomes fundamental for those patients (109)

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