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Consistent with the suppression of mTORC1 signaling, we observed that cystine starvation markedly activated the ISR (Fig

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Zheng WV, Li Y, Cheng X, Xu Y, Zhou T, Li D, Xiong Y, Wang S, Chen Z

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Mechanistically, this may relate to GHK-Cu's ability to upregulate matrix metalloproteinases (MMP-1, MMP-2), enzymes that can fragment collagen if their activity exceeds the body's ability to rebuild