metformin vs glp 1 Comparison of type 2 diabetes medications: GLP-1RA, SGLT2i, and Actions of metformin on metabolism

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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state

Increasing your glutathione levels may help with this process, resulting in fewer toxins in your liver

Ding C, Tang Y, Zhu W, et al

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Other common gastrointestinal effects include: Vomiting (5-24% of patients) Diarrhea (8-30% of patients) Constipation (10-24% of patients) Abdominal pain or discomfort (5-20% of patients) These side effects are typically most pronounced when initiating therapy or increasing doses, and often diminish over time as the body adjusts to the medication