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GSH is formed from LC by the enzymatic action of glutamate-cysteine ligase ( GCL ) and GSH synthetase (18)

3 , e53 (2005)

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Ultimately, the compounding effect of NO and oxidative damage within the mitochondria can spiral into a vicious cycle, where increasing respiratory inhibition produces more free radicals, which further increases respiratory inhibition and induces cell death (Poderoso et al., 2019