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The renoprotective effect of L-carnitine in hypertensive rats is mediated by modulation of oxidative stress-related gene expression

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This explains why vomiting is more common during dose escalation and why gradual titration protocols are recommended in clinical practice

Subjects receive oral semaglutide 3 mg + placebo, or semaglutide 7 mg + placebo, or semaglutide 14 mg + placebo, or oral sitagliptin 100 mg + placebo [78]