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Sithole MN, Marais S, Maree SM, Du Plessis LH, Du Plessis J, Gerber M

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Neutrophils, recruited to the inflamed joint, release factors like TNF-, IL-1, and CXCL8, exacerbating the inflammatory response

Hepatic cytochrome P450 enzyme activity and renal clearance efficiency both decline with age, which could theoretically extend the dihexa half life in older subjects, but specific pharmacokinetic data stratified by age are not published for dihexa

Some people prefer to take a sublingual (under the tongue) daily supplement or a monthly injection of B12 as both of these methods bypass the digestive system and help avoid poor absorption issues