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The tissue becomes tender

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Some of the serious side effects of Vitamin B12 include serous allergic reaction, narrowing or blocking of blood vessels, thrombocytosis (a disorder where your body produces too many platelets), low potassium levels in body, pulmonary edema (a condition where there is excess fluid in the lungs) and congestive heart failure

Short-term (weeks to months), the refrigerator is fine

Formulated with 0.9% benzyl alcohol as a preservative , it is designed to inhibit microbial growth, allowing for multi-use applications within controlled research settings