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Research indicates that individuals with BP-I remain symptomatic for nearly half of their illness course, with depressive symptoms being the most frequent and persistent, significantly outweighing manic/hypomanic and mixed episodes (Nierenberg et al., 2023)

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J Nanobiotechnol 14:120 Constantino VRL, Figueiredo MP, Magri VR, Eullio D, Cunha VRR, Alcntara ACS, Perotti GF (2023) Biomaterials based on organic polymers and layered double hydroxides nanocomposites: drug delivery and tissue engineering