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Materials and methods Experimental design and induction of the PCOS rat model The ethics committee of Shiraz University of Medical Sciences approved the study protocol (IR.SUMS.AEC.1403.010)

Protein concentration was determined using a BCA Protein Kit (Thermo, Rockford, IL, United States)

122,123,124 Restoring the balance between M1 and M2 macrophages not only regulates the expression of inflammatory factors but also maintains the physiological function of the intestinal barrier, regulating the dynamic balance of the intestinal microbiota to ameliorate UC