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Studies have suggested the association of c-MET expression with expression of immunoregulatory molecules such as programmed cell death ligand (PDL-1) and indoleamine-2,3-dioxygenase (IDO) in cancer cells [69]

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We investigated whether ALCAR is able to interfere in vitro with the expression of TNF-, together with other pro-inflammatory cytokines/chemokines such as IL-6, CCL2, as well as CXCL12 and its receptor CXCR4 on PCa (PC-3, DU-145, LNCaP) and BPH cells