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British Journal of Pharmacology, 148(3), 245-254

Circulating lipoprotein (a) [Lp(a)] levels are primarily determined by the LPA gene locus 12

Furthermore, in a BK5.IGF-1 mouse model of breast cancer, elevated levels of IGF-1 expression activated the COX-2/PGE2/EP3 signaling pathway, accompanied by increased VEGF expression and tumor angiogenesis (110)

Key points: GI side effects are most common: nausea, diarrhea, and decreased appetite They usually improve: most patients adapt within 4-8 weeks Start low, go slow: the escalation schedule exists for a reason Stay hydrated and modify your diet: simple changes make a big difference Communicate with your provider: don't suffer unnecessarily Sources SURMOUNT-1 Clinical Trial (Jastreboff et al., NEJM 2022) SURPASS-1 Clinical Trial (Rosenstock et al., NEJM 2021) Mounjaro Prescribing Information, Eli Lilly Zepbound Prescribing Information, Eli Lilly Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice

Our patients in NJ find that when we address these hormonal barriers, weight loss becomes a sustainable reality rather than a temporary struggle

Go for options like Greek yoghurt, a small protein pudding, a ready-to-drink protein shake, or soft fruit such as banana or berries