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Nicotinamide adenine dinucleotide , or NAD , is a vital coenzyme in every living cell

In contrast, cells with lower senescence burden may have less FOXO4p53 dependence, or may buffer p53 relocalization through other regulators, which might explain the limited apoptosis in younger cultures compared to aged cell cultures

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doi 10.1093/ecco-jcc/jjaf167 104 BergenholtzSGoldSSpencerEAFreidHMarionJFWongS-Y