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The Ni-NTA bead suspension was transferred to 5-ml disposable chromatography columns (29922, Thermo Fisher Scientific)

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In contrast, semaglutide, liraglutide, and dulaglutide undergo proteolytic degradation with minimal renal clearance, making them suitable options for patients with renal impairment, though caution is still advised

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This is a controversial therapy because of these concerns, and research into this potential treatment is ongoing