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McConeghy KW, Caffrey AR, Morrill HJ, Trivedi AN, LaPlante KL

A systematic review and meta-analysis in adults with chronic constipation found that probiotic supplements improved stool frequency, stool consistency, and the time it took food to move through the colon ( The authors concluded that the probiotic strain Bifidobacterium lactis was the most effective ( Meanwhile, a 2017 review of 21 studies in people with constipation suggested that taking probiotic supplements that contain Lactobacillus or Bifidobacterium species may increase stool frequency and reduce foods transit time through the colon ( However, a review of 18 meta-analyses suggested that existing studies on probiotics and constipation are of low quality

GLP-1 medications work by binding to receptors that control hunger signals and glucose metabolism, creating a more comprehensive metabolic effect than phentermine alone