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It thus makes sense that even mice that have been engineered to overproduce beta-amyloid have lower levels of beta-amyloid in their brain if they had been raised germ-free than if they had not (Harach et al., 2017

Its particularly common in children who suck their thumbs and healthcare professionals who come into contact with patients mouths without gloves

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An immunoglobulin produced by activated B-cells and plasma cells after exposure to an antigen with specificity for the inducing antigen

444 Moreover, the transcriptional complex formed by TAZ and TEAD4 has two binding sites in SOX2 promoter, which in turn facilitates transcription of SOX2, leading to the self-renewal property and maintenance of the cancer stem cell population in HNSCC cells