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The brainstem-cortex network plays a critical role in the migraine pathway, with conditions such as insomnia, obstructive sleep apnea, sleep-related movement disorders, and REM sleep disturbances closely associated with migraine onset (Vgontzas and Pavlovi, 2018)

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The possibility that GSHee directly blunted the mechanisms by which fentanyl depressed breathing is supported by the evidence that GSHee did not affect baseline Vt values but markedly blunted the magnitude and duration of fentanyl-induced reduction fentanyl-induced reduction in Vt

Small, evidencealigned nudges can still be meaningful when combined with good training, sensible nutrition, and adequate sleep