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The efferocytosis of those cells leads to a decrease of MHC-II as well as CD80, CD86, and CD40, and an increase of programmed death-1 ligand 1 (PD-L1) expression

2.1 Trimethylamine-N-oxide and betaine in humans In humans, TMAO is mostly biosynthesized from the unabsorbed dietary constituents containing trimethylamine moiety such as choline (concentrated in egg yolk and liver) and L-carnitine (predominantly in red meat) through the activity of inhabitant bacteria of the human large intestine (Li et al., 2018a) (Figure 2)