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Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis

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The nuclear factor erythroid 2-related factor 2 (Nrf2)- glutathione peroxidase 4 (GPx4) axis was involved in carbon tetrachloride (CCl4)-mediated acute liver injury in mice ( Figure 1 The role of ferroptosis in liver diseases Ferroptosis and liver injury Acute liver injury without any underlying liver diseases includes drug-induced liver injury, IRI, and liver injury caused by acute viral infection

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