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Most striking, IAPP toxic oligomers appear to disrupt membranes of the secretory pathway, and then when adjacent to mitochondria, disrupt mitochondrial membranes ( Figure 4 illustrates schematically the process by which Akkermansia spp protect the host from type II diabetes

The synthetic triterpenoid CDDO-me is an effective inhibitor of the leukemia-associated de novo angiogenesis

He has published over 1000 scientific articles, filled over 60 patents, and supervised over 80 PhD students