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Silent information regulator 1 (SIRT1), an NAD + -dependent deacetylase, functions as a central regulator of metabolic homeostasis and a key mediator in immune microenvironment remodeling and inter-organ communication

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Among the 40 differently expressed genes identified by RNA-Seq, the downregulation of alpha-methylacyl-CoA racemase (AMACR) and androgen receptor long non-coding RNA 1 (ARLNC1), both associated with PCa, was particularly notable

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Increased oxidative stress and energy depletion contribute to cellular dysfunction and apoptosis, highlighting the need for antioxidant therapies