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Conversely, in gout, reduced bile acid levels lead to diminished TGR5 activity, which in turn results in reduced GLP-1 secretion, and weakened inhibition of both the NF-B pathway and NLRP3 inflammasome

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Its stability profile makes it particularly attractive for long-term industrial contracts requiring predictable outcomes

Natelson BH, Weaver SA, Tseng CL, Ottenweller JE

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[5] In the same 28-day study, DIO mice showed reduced body weight and fat mass gains alongside improved glucose tolerance and attenuated hepatic steatosis