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Common indicators include: Elevated homocysteine levels (above 10-15 mol/L) Chronic fatigue and low energy Anxiety, depression, or brain fog Hormonal imbalances (PMS, infertility, irregular periods) Recurrent miscarriages or pregnancy complications Cardiovascular issues (high blood pressure, blood clots) Digestive problems (IBS, bloating, food sensitivities) Chronic inflammation or autoimmune conditions Many people discover they have an MTHFR mutation after experiencing unexplained health issues or through genetic testing ordered by their healthcare provider