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Gastrointestinal Tolerance and Bedtime Dosing Nausea and gastrointestinal side effects occur in 20-40 percent of semaglutide users, typically peaking within the first two weeks of therapy or after dose escalation

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Because gastric emptying slows significantly on this medication, high-fat, spicy, fried, and heavily processed foods can amplify nausea, heartburn, and bloating considerably

Additional studies have consistently shown that GLP-1 agonists improve systolic and diastolic blood pressure readings, particularly in patients who achieve significant weight loss