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Adherence to the dose escalation schedule This is the most controllable factor

10.1007/s10557-025-07670-9 159 ZhaoH.WangL.WeiR.XiuD.TaoM.KeJ.et al (2014)

"That looks very far from the standards one would expect from a manufacturing facility

You need to experience the full effect of each dose before deciding whether escalation is appropriate