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Safety A treatment-emergent adverse event (TEAE) was defined as an adverse event (AE) that occurs or worsens after receiving a treatment or intervention

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (Ukpds 34)

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A more granular sensitivity analysis was not performed, as the included studies demonstrated consistent effect estimates with overlapping confidence intervals and no substantial influence of individual studies on the pooled outcomes

1986, pp