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Tang Y, Luo H, Xiao Q, Li L, Zhong X, Zhang J, et al

In the nervous system, oral administration of saikosaponin D to mice at 4 and 8 mg/kg for 7 days or 16 mg/kg for 14 days leads to cognitive decline, suppressed hippocampal neurogenesis, and inhibited proliferation and survival of neural stem/progenitor cells

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Other D2 receptor antagonists, including domperidone, may improve symptoms to a comparable extent to metoclopramide [70]

If 5 mg works well and side effects are manageable, some providers will keep patients at this dose for an additional 4 weeks before increasing