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As Professor Ildiko Lingvay from the University of Texas explained at the 2025 IFSO World Congress, Once treatment stops, weight tends to come back. Cost is another major issue

Antoniou C, Chatzimichail G, Xenofontos R, Pavlou JJ, Panagiotou E, Christou A, Fotopoulos V

Strategies to minimize immunogenicity include careful peptide design to maintain similarity to natural sequences, appropriate formulation development, and monitoring for antibody formation during clinical development and post-market surveillance

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This flexibility is one advantage of the integrated telehealth model over pharmacy-only providers where patients manage their own dosing