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However, "long-term" doesn't necessarily mean "forever." Some patients successfully maintain weight loss after discontinuation through sustained behavioral changes, consistent exercise routines, and modified dietary patterns developed during therapy

de Luca C, Olefsky JM

Anderson, MD, MAS, an assistant professor of medicine from the University of Pittsburgh, clinical trials of several GLP-1 receptor agonists like semaglutide (Wegovy/Ozempic, Novo Nordisk) for weight loss included exclusion criteria of chronic medical and psychiatric conditions. However, [FDA] labeling does not restrict these treatments in these populations, they wrote in JAMA Internal Medicine

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