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The closest safety dataset is the Increlex (mecasermin) clinical program , which followed 71 pediatric patients with severe primary IGFD on twice-daily SubQ rhIGF-1 for a mean of 3.9 years (some patients up to 11.5 years)

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Day 1: 100-200mg NAD IV (1-4 hrs) Day 4: 25mg NAD SQ Day 6: 25mg NAD SQ Daily: 250mg NR/NMN in the morning Week 2 We increase the SQ shots here to extend the life of the initial IV dose of NAD