It is worth noting that despite the potential benefits of GLP-1RA, evidence from the SUSTAIN-6 clinical trial suggests that GLP-1RA may be a risk factor for DR, whereas the clinical trial from LEADER demonstrated that the two are not related [1, 6]
Therefore, it does not increase hematocrit or blood viscosity
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Neuroimaging indicates that each can reduce activity in the insula, a region that integrates bodily hunger signals and reward-related cravings
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Ethics statement The studies involving humans were approved by Centro Hospitalar de Entre Douro e Vouga (approval numbers: CA-0172/19-0t_MP/AC and CA-149/ 2020-0t_MP/AC)