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This suggests a very good safety and tolerability profile indistinguishable from placebo in those trial settings

Specifically, magnesium is required by several enzymes involved in the citric acid cycle and electron transport chain---mitochondrial processes that help turn the carbohydrates, proteins, and fats consumed in our diet into ATP

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There is a theoretical --- though as yet unproven in humans --- risk that long-term or high-dose use could stimulate growth in existing malignant or pre-malignant cells