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2 Circulating levels of IGF-1 vary greatly depending on a number of intrinsic and extrinsic factors, including age, gender, genetics, nutritional status, physical activity and stress

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This is based on the observation that the livers of GCLM KO mice in all diet groups have high levels of active (phosphorylated) LKB1, a redox-sensitive kinase and the primary hepatic AMPK kinase 24

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Journal of cosmetic dermatology, 21(2), 802813