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Only surgical excision can physically tighten loose, hanging skin after major weight loss

Use of this drug should be avoided during pregnancy

Abbreviations 3-MA: 3-Methyladenine ADSC: Adipose-derived stem cell DEG: Differentially expressed gene ROS: Reactive oxygen species LPOs: Lipid peroxides OGD: Oxygen and glucose deprivation MDA: Malondialdehyde SOD: Superoxide dismutase Fer-1: Ferrostatin-1 GSH: Glutathione H&E: Hematoxylin and eosin KEGG: Kyoto Encyclopedia of Genes and Genomes MRI: Magnetic resonance imaging NAC: N -Acetylcysteine Nec-1: Necrostatin-1 NS: Normal saline PBS: Phosphate-buffered saline qRT-PCR: Quantitative real-time polymerase chain reaction SD: Standard deviation TEM: Transmission electron microscopy References Smith P, Adams WP Jr, Lipschitz AH, Chau B, Sorokin E, Rohrich RJ, Brown SA

However, they provide some preliminary compelling data suggesting future randomized trials are warranted

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