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The Pathomechanism and Role of IR in PCOS IR is an impairment of insulin effect on cells, especially muscle cells, adipocytes, and hepatocytes
J Cell Sci 117:25912598 Acknowledgements RKT is grateful to DST SERB, New Delhi, for Teachers Associateship for Research Excellence (TAR/2019/000064)
Each approach has genuine trade-offs
These follicles develop slowly and remain morphologically inactive within the ovarian cortex
Comparisons With Other Diabetes Therapies Putting GLP1s in context with other antidiabetic agents offers additional insights: Thiazolidinediones (TZDs) are associated with increased fracture risk, especially in women SGLT2 inhibitors have raised concerns in some trials, particularly canagliflozin DPP-4 inhibitors appear largely neutral regarding skeletal effects Against this backdrop, GLP1s may have a neutral or possibly safer profile, though the data are not conclusive
