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The simulations suggested that quinone metabolism yielded an increase in ROS (O 2 . and H 2 O 2 ), producing a maximum of 0.42 M and 1 10 3 M respectively

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Individuals commonly report: Vivid or disturbing dreams Headaches Insomnia Excessive sweating Gastrointestinal issues (vomiting, diarrhea) Tremors Irritability or agitation Confusion Dizziness Pins and needles sensations Irregular heartbeat Blurred vision Ringing in the ears (tinnitus) Depression or heightened anxiety Light flashes and electric shock-like feelings in the limbs and brain Discontinuation syndrome may further manifest as nausea, sensory disturbances, flu-like symptoms, balance problems, and heightened emotional responses (hyperarousal)

Efforts have been made to reduce the nephrotoxicity caused by cisplatin

Key studies to be aware of: Pickart et al