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Overexpression of glutathione S -transferase alpha in clear cell renal cell carcinoma

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observed that esaxerenone, a nonsteroidal selective compound, effectively decreased the expression of MCP-1 and inhibited the infiltration of inflammatory cells in DKD by suppressing ROS levels (212)

In conclusion, GLPs maintain the homeostasis of the renal microenvironment and alleviate renal fibrosis through multiple targets, such as anti-oxidation, anti-inflammation, anti-apoptosis, regulation of lipid metabolism, and blocking relevant pathways, formulating a theoretical framework to support the research and creation of novel pharmacological treatments for nephropathy