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Importantly, it enabled discrimination between human-specific and animal-specific toxicities, such as those induced by bosentan (an endothelin receptor antagonist with known dose-dependent human hepatotoxicity) and fialuridine (an antiviral nucleoside analog that caused fatal human liver toxicity undetected in animals), thereby improving the extrapolation of preclinical findings to human outcomes

Mitochondria are the major source of reactive oxygen species (ROS) in cells

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B12 can also be administered with subcutaneous fluid therapy

Perspectives and conclusions As discussed above, intracellular ROS homeostasis is a fundamental aspect of cell physiology

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