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Similarly, in the CANVAS outcome study, discussed in detail below, LDL cholesterol and HDL cholesterol were also marginally increased in the canagliflozin treated group (LDL cholesterol 4-5 mg/dL and HDL cholesterol 2-3 mg/dL) (144)

Bay-Jensen AC, Mobasheri A, Thudium CS, et al

Additionally, certain supplements, like potassium citrate, may help in maintaining a healthy urinary environment, making it less conducive to stone formation

Review any medication changes that coincided with apparent efficacy loss

Cha SA, Park YM, Yun JS, Lim TS, Song KH, Yoo KD, Ahn YB, Ko SH