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Jabbour E, Verstovsek S, Gandhi V, Cortes J, Giles F, OBrien S, Plunkett W, Garcia-Manero G, Kantarjian H, Andreeff M

( A ) Mouse caSMCs were transfected with a combination of 4 MTP-specific siRNAs, and relative Mtpa mRNA expression was measured by reverse transcription PCR versus control siRNA

This trend may favor peptide therapeutics that demonstrate superior effectiveness or safety profiles

Reasonably consistent across animal and human observational work

Importantly, these trials revealed net cardiovascular benefits, including reduced rates of heart attack and stroke in patients with existing heart disease

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