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Obesity and metabolic disorders are also commonly linked to reproductive issues such as polycystic ovary syndrome (PCOS) 95 and erectile dysfunction (ED) 96

4 Challenges of targeted glutamine metabolism for Cancer treatment Although targeting glutamine metabolism in cancer cells is a promising strategy, there are still many obstacles that need to be overcome to clinical outcomes

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Furthermore, Spim et al

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In the same manner as ROS cause PR damage, iron overload can cause lipid peroxidation and oxidative stress, leading to ferroptosis and subsequent PR damage (166)