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VDR regulates genes critical for intestinal homeostasis, including those encoding tight junction proteins like claudins, thus preserving the integrity of the intestinal barrier and modulating inflammation [45]

Long-term, improved insulin sensitivity often translates to a reduced risk of T2D, high blood pressure, heart disease, and other cardiometabolic disease, all of which grow more prevalent in midlife

The nitroalkylation process occurs and in vivo, is involved in redox processes and cell signaling through the reversible covalent bound and post-traslational modifications responsible for structure, function and subcellular distribution of proteins (Valdez et al., 2011) and regulating the pro-inflammatory effect of oxidant exposure (Nair et al., 2007)