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Therapeutic effects of N-acetyl-L-cysteine on liver damage induced by long-term CCl4 administration

GLP-1 agonists are already being used beyond weight loss and glucose control

The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

doi: 10.1126/sciadv.abg1371 337 Wendelaar BongaS

Your provider can help determine whether the benefits justify the monitoring demands and potential risks in your specific situation