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It is generally safe when used as prescribed, but may cause irritation or dryness, especially during the initial phase

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10.1016/j.freeradbiomed.2015.05.008 [DOI] [PMC free article] [PubMed] [Google Scholar] Colombi A, Tagliavini R, Lucchelli PE (1969) Paired comparison among 3 drugs with topical action in an experimental pattern with incomplete blocks

Curcumins chemical makeup generally renders it less soluble in water at both neutral and acidic pH values