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This interval, called perimenopause, is the adaptive reproductive phase, where there begin to be inconsistent oscillations in ovarian estrogen production as the follicles respond to gonadotrophin waves of follicle-stimulating hormone (FSH) [10]

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T.et al (2012)

Food and Drug Administration has not labeled these drugs as safe for lactating mothers since no controlled studies have been done on humans

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Reviewers, including the Indian Journal of Dermatology, Venereology and Leprology paper on this exact topic, note that how long brightening lasts after stopping hasn't been properly studied yet treat it as maintenance, not a one-time fix